Men's Health Care &
Testosterone Therapy

In-depth guide

A plain-language guide to testosterone and enclomiphene therapy

Low testosterone, sometimes called male hypogonadism, means the body is not making as much testosterone as it should. It can bring tiredness, lower sex drive, and low mood. Many other things, such as poor sleep, stress, and certain medicines, can cause the same symptoms, so symptoms alone are not enough to diagnose it. Low testosterone is confirmed with symptoms plus repeated blood tests.

Prolong Health offers two men's health programs through licensed telehealth providers: testosterone therapy and enclomiphene therapy. Prolong Health itself does not practice medicine. Clinical care is provided by licensed providers through our partner, Agile Telehealth. A provider decides whether treatment is right for you after reviewing your intake and lab results. This guide explains how that works and what the risks are.

How the program works, step by step

1. Step 1: Complete your intake and initial labs. You fill out a health intake and pay a $50 initial lab panel up front. Blood is drawn in person at a Quest or Labcorp location.
2. Step 2: Live video visit. A video visit is scheduled in advance. Your provider reviews your labs and history with you and decides whether treatment makes sense.
3. Step 3: Treatment starts, if appropriate. If your provider prescribes treatment, you take it as directed. For testosterone therapy, the options are testosterone cypionate as an injection, a gel, or an oral form, paired with anastrozole. For enclomiphene therapy, the dose is 12.5 or 25 mg as an orally disintegrating tablet (ODT), also paired with anastrozole.
4. Step 4: Quarterly labs and reviews. Labs and provider reviews happen every quarter. For testosterone therapy, the quarterly refill review is a live visit. For enclomiphene therapy, refill reviews are done asynchronously, which means you and your provider exchange information online without a scheduled call.
5. Step 5: Annual lab panel. Once a year, a full annual lab panel takes the place of the fourth quarterly lab.
6. Step 6: Care coaching along the way. You get a 15-minute coaching session at the start, then monthly check-ins. Coaches help with habits and questions. They do not prescribe medication or change doses.

What's included

• Provider review of your intake and lab results by a licensed provider
• In-person lab monitoring, included in the every-4-weeks price (the initial $50 panel is separate)
• Quarterly provider reviews and an annual lab panel
• Care coaching and your medication, if a provider prescribes it

Pricing summary

Testosterone therapy is $169 every 4 weeks, and enclomiphene therapy is $189 every 4 weeks. Both include in-person lab monitoring. Both also require the $50 initial lab panel, paid up front.

Prolong Health is cash-pay. We accept FSA and HSA cards, Visa, Mastercard, Apple Pay, and Google Pay, but not American Express.

You can cancel anytime. You can ask for a refund at any time, except for a month in which your medication has already been ordered.

Testosterone therapy is offered only in certain states and D.C., and availability can change with regulation. Enclomiphene therapy is available in all 50 states and D.C.

Eligibility, safety and side effects

Every treatment has trade-offs. The points below are general information from public drug references, not a complete list and not advice for you. Your provider will go over your own risks, and you should read the medication guide that comes with any prescription. Testosterone is a controlled substance (Schedule III), so extra safeguards apply, including the required live visit for your first prescription and for quarterly refills.

Common side effects

• Acne or oily skin
• Breast tenderness or breast enlargement
• Swelling and mood changes
• Higher red blood cell count (hematocrit), which is why labs are checked regularly
• Lower sperm production, which can reduce fertility
• With gels: the medicine can transfer to other people through skin contact, so the area should be covered and hands washed

Serious risks and warnings

• Testosterone can make sleep apnea worse.
• Questions about heart and blood vessel risk need a provider's evaluation, and some testosterone products have been linked to higher blood pressure.
• Prostate health is part of the evaluation, and testosterone should not be used with certain cancers.
• Anastrozole is an aromatase inhibitor. It is used here off-label in men to help manage estrogen. Off-label means it is not approved by the FDA for this use.
• Enclomiphene is a compounded medication. It is not FDA-approved, and the FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed. Data on it is limited. Its effects on fertility are something to discuss with your provider before starting.
• Call 911 for chest pain, shortness of breath, sudden weakness on one side, or trouble speaking.

Tell your provider about every medicine and supplement you take, and about any heart, prostate, liver, or breathing problems. Report new symptoms promptly. Treatment is never guaranteed, and results vary from person to person.

Sources and further reading

• MedlinePlus (U.S. National Library of Medicine): Male hypogonadism
• Endocrine Society: Hypogonadism in men
• Hormone Foundation: Low testosterone
• MedlinePlus (U.S. National Library of Medicine): Testosterone injection
• MedlinePlus (U.S. National Library of Medicine): Anastrozole
• U.S. Food and Drug Administration: Compounding and the FDA, questions and answers

Frequently asked questions