Research on NAD+ in humans is limited, and there is no established evidence that taking NAD+ by injection, nasal spray, oral drops or IV improves energy, slows aging, or extends life in otherwise healthy adults. Some people report feeling better, but that is not proof.

Longevity & Wellness

NAD+ Therapy: What It Is, What It Costs, and Who It's For

Q: How much does NAD+ cost without insurance?

Through Prolong Health's telehealth program, NAD+ is $229 per 4 weeks as an injection, nasal spray or daily oral liposomal. In-home NAD+ IV therapy in the Tampa Bay area is $499 for 250 mg (about 2 hours) and $769 for 500 mg (about 4 hours) per session.

Q: Can I use an HSA or FSA for NAD+?

Prolong Health accepts FSA and HSA cards for payment. Whether your plan treats a particular purchase as an eligible expense depends on your plan, so check with your plan administrator.

Q: What are the side effects?

Reported effects include pain or redness at the injection site, flushing, nausea, chest tightness and cramping, especially when NAD+ is delivered quickly. Tell your provider about every medicine and supplement you take, and whether you are pregnant or breastfeeding.

Q: Will I definitely be prescribed NAD+?

No. A licensed provider reviews your intake and decides whether it is appropriate for you. Completing an intake never guarantees a prescription.

NAD+ therapy explained: what the research does and doesn't show, the forms it comes in, what it costs online and at home, and what to ask before you start.

Published August 30, 2026 · Updated October 4, 2026

NAD+ is one of the most talked-about wellness products online, and one of the least clearly explained. This guide covers what it is, what the research does and does not show, the forms it comes in, and what it costs, including the NAD+ options on our longevity treatment page and our in-home IV therapy in Tampa Bay. It is general information, not medical advice.

What NAD+ Actually Is

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell in your body uses for energy metabolism. It works inside your mitochondria — the part of the cell responsible for producing energy — where it plays a central role in the electron transport chain and ATP production.^[1] Research on whether NAD+ levels decline with age is more nuanced than often claimed: several studies show tissue-specific declines (notably in blood and brain), while the picture across the body as a whole is still being studied.^[2] Interest in NAD+ has grown alongside broader interest in mitochondrial health and longevity.

What the Evidence Does and Doesn't Show

Your body makes NAD+ on its own, and it matters for how cells work. That is different from showing that adding more NAD+ by injection, nasal spray, oral drops or IV makes a healthy person feel or function better. Human research on supplemental NAD+ is limited, and higher blood levels on their own have not been shown to guarantee better outcomes. NAD+ is not approved by the FDA to treat aging, low energy, or any condition, and compounded versions are not FDA-approved.^[3] Some people say they feel better; that is not proof it works.

The Forms NAD+ Comes In

Injection (telehealth). Prescribed by a licensed provider, prepared by a compounding pharmacy, and shipped to you.
Nasal or oral drops (telehealth). Other prescribed forms offered through the same program, at the same price.
IV infusion (Tampa Bay only). Delivered at home by a licensed registered nurse in the Tampa Bay, Florida area, in 250 mg or 500 mg sessions.

We do not claim that one form works better than another. The right choice, if any, depends on your health history and what a provider decides is appropriate.

Who NAD+ Therapy Is For, and Who It Isn't

NAD+ is typically sought out by adults interested in energy, recovery or general wellness. It isn't a treatment for a diagnosed condition, and whether it's appropriate depends on your health history. It is not for people who are pregnant, trying to become pregnant or breastfeeding, or anyone expecting a guaranteed result. That is why every patient goes through a real intake and provider review first.

What NAD+ Therapy Costs

Prices below are cash-pay. Prolong Health does not bill insurance, and accepts FSA and HSA cards.

Telehealth NAD+ (shipped to you, nationwide where available)

NAD+ injection: $229 per 4 weeks
NAD+ nasal spray: $229 per 4 weeks
NAD+ oral liposomal (daily): $229 per 4 weeks

The price covers your provider review and, if prescribed, the medication, with scheduled refill reviews.

In-home NAD+ IV therapy (Tampa Bay only)

250 mg (about 2 hours): $499 per session
500 mg (about 4 hours): $769 per session

Glutathione, often paired with NAD+ as an antioxidant complement, is $149 per 4 weeks on the telehealth plan. Methylene blue tablets and L-carnitine injections are also $149 per 4 weeks, and B12 MIC is $145.

What Affects the Price

The plan length: 4, 12 or 24 weeks.
The form: a monthly telehealth program or a one-time at-home IV session.
The dose and how often it is prescribed, decided by your provider.
Whether provider reviews, refills and shipping are included in the price.

Questions to ask before you buy NAD+ anywhere

Who reviews my health history, and is that review included?
Is the product compounded, and by a licensed pharmacy?
What dose will I get, and how often?
What does a refill cost, and can I cancel?
What do you say about results, and is it backed by evidence?

NAD+ vs. Glutathione

NAD+ supports cellular energy metabolism. Glutathione is an antioxidant your body makes on its own. Some patients ask about one, some about both; evidence for benefit from either by injection in healthy adults is limited. Your provider can help you decide what, if anything, fits.

Safety and Side Effects

Reported effects of NAD+ include pain, redness or swelling at the injection site, headache, and flushing, nausea, chest tightness or cramping, particularly when it is delivered quickly. Tell your provider about every medication and supplement you take. If you have chest pain, trouble breathing or a severe reaction, call 911.

Frequently Asked Questions

Is NAD+ therapy FDA-approved?

No. Compounded NAD+ is not FDA-approved, and the FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed. NAD+ is not approved to treat aging, low energy, or any specific condition.

How much does NAD+ cost without insurance?

Can I use an HSA or FSA for NAD+?

Does NAD+ work?

What are the side effects?

Will I definitely be prescribed NAD+?

How to Get Started

Complete an intake, get reviewed by a licensed provider, and if appropriate, start treatment. Not sure it's for you? Read our explanation of who provides your care, browse common questions, or find care in your state.

Start Your Longevity & NAD+ Evaluation